FDA Investigation into Potential Link between Certain Diets and Canine Dilated Cardiomyopathy

The per capita alcohol consumption of 9.7 l pure ethanol and the early onset of regular or episodic intensive drinking among young people in Germany consequently leads to high alcohol-related morbidity and mortality [5]. The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment.

alcoholic cardiomyopathy

The preponderance of data suggests that drinking one to two drinks in men and one drink in women will benefit the cardiovascular system over time. Moderate drinking below that threshold might even reduce the incidence of coronary artery disease, diabetes, and heart failure. In 1887, Maguire reported on 2 patients with severe alcohol consumption who benefitted from abstinence.

Cardiovascular Research

For that reason, transplant programs have very strict list requirements to qualify for a transplant and abstaining from alcohol is almost always on those lists. The muscles that control the lower chambers of your heart, the left and right ventricle, are especially prone to this kind of stretching. These chambers are important as they do the majority of the work of your heart, with the right ventricle pumping blood to your lungs and the left ventricle pumping blood to your entire body. Weakening in the muscles around the ventricles means they can’t pump as hard, which negatively affects your entire body. Alcohol-related cardiomyopathy is a type of dilated cardiomyopathy, which is when your heart’s shape changes because its muscles are stretching too much. The effect is much like how a rubber band or spring weakens when stretched too much.

That scar tissue can also cause potentially life-threatening arrhythmias (irregular heart rhythms). Some studies have suggested that even moderation of alcohol consumption similar outcomes as compared to abstinence. Untreated https://ecosoberhouse.com/ ACM can become severe and have life-threatening consequences, causing irregular heartbeats and congestive heart failure. Manhattan Cardiology is the premier facility for cardiac testing and preventive treatment in New York.

Differential Diagnosis

Call your doctor right away if you think you have alcoholic cardiomyopathy. Prompt treatment can help prevent the disease from getting worse and developing into a more serious condition, such as congestive heart failure (CHF). Completely abstaining from alcohol is the key recommendation if you have alcohol-induced cardiomyopathy.

When the cardiovascular system is exposed to ethanol, acute and chronic changes occur in both systolic and diastolic functioning, with the most significant being a depression in contractility. If alcohol consumption continues, 40–50% of patients will die within 3–6 years [30], because continued consumption leads to further myocardial damage and fibrosis. The metabolites of alcohol, acetaldehyde and acetate, can have direct toxic effects on the heart as well. Complete abstinence may stop the progression of heart failure or even allow for recovery in early stages [31–33]. All patients with severe ventricular dysfunction, regardless of cause, should avoid alcohol because of the risk for worsening of their heart failure. Excessive intake of alcohol may result in increased systemic blood pressure in a dose-response relationship, and this may contribute to chronic myocardial dysfunction.

How Alcohol Affects Heart Failure

Polyphenols of red barrique wines and flavonoids have been shown to inhibit endothelin-1 synthase [102] and PDGF-induced vasoproliferation thus also contributing to cardiovascular protection [103]. Palpitations, dizziness, and syncope are common complaints and are frequently caused by arrhythmias (eg, atrial fibrillation, flutter) and premature contractions. In the setting of acute alcohol use or intoxication, this is called alcoholic cardiomyopathy is especially dangerous because holiday heart syndrome, because the incidence is increased following weekends and during holiday seasons. Some studies have suggested that a genetic vulnerability exists to the myocardial effects of alcohol consumption. Individuals with certain mitochondrial deoxyribonucleic acid (DNA) mutations and angiotensin-converting enzyme (ACE) genotypes (DD genotype) may be particularly susceptible to the damaging effects of alcohol.

It is a condition that develops over a long period of frequent and heavy drinking. Chronic alcohol use can have long-lasting effects on a person’s quality of life and health. Heavy drinking can weaken the ability of several vital organs in the body to work properly over time and result in serious damage. One of the most important organs in the body that can be harmed through alcohol use is the heart.

For example, it can have a pressor effect, cause hypertension, and increase left ventricular mass [34]. Those who drink heavily may experience substantial increases in their blood pressure. Alcohol consumption may also lead to deficiencies in magnesium, potassium, phosphorus, and thiamine, which may further exacerbate existing dysfunction. Alcohol can also worsen hyperlipidemia, primarily by elevating the triglyceride levels, although it can also increase both the total cholesterol and low-density lipoprotein concentration [35]. In smaller quantities (less than 1–2 ounces a day), the high-density lipoprotein levels typically increase, thus alcohol may exert a slightly favorable effect.

In addition, Vet-LIRN has contracted with a network lab to collect blood (whole blood and plasma), urine, feces, and DNA from dogs without a known breed predisposition to DCM (as a point of comparison) to send to Vet-LIRN for testing. Animal protein sources in the reported diets varied widely, and many diets contained more than one protein source. The most common proteins in the reported diets were chicken lamb and fish; however, some diets contain atypical protein sources such as kangaroo, bison or duck. What’s more, alcohol can contribute to obesity and the long list of health problems that can go along with it. Alcohol is a source of excess calories and a cause of weight gain that can be harmful in the long term.

In 1890, Strümpell listed alcoholism as a cause of cardiac dilatation and hypertrophy, as did Sir William Osler in 1892 in his textbook Principles and Practices of Medicine. In 1893, Graham Steell, well known for the Graham Steell murmur due to pulmonary regurgitation in pulmonary hypertension or in mitral stenosis, reported 25 cases in whom he recognized alcoholism as one of the causes of muscle failure of the heart. In his 1906 textbook The Study of the Pulse, William MacKenzie described cases of heart failure attributed to alcohol and first used the term “alcoholic heart disease” [26].

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